Men with azoospermia do not have sperm in their semen after ejaculating. This illness is rare and only affects one man in every one hundred. It is a severe case of male infertility; however, it is uncommon. You are less likely to conceive if your spouse has this illness naturally. If you wish to have a family but have azoospermia, ART therapies may be able to help. Azoospermia is treated depending on the underlying reason and the female’s fertility.

Types of azoospermia

There are two types of azoospermia, including:

  • Obstruction Azoospermia: In this disease, sperm are produced in the testicles but cannot leave the body because of a blockage in the reproductive canal. This obstruction may be present in the epididymis, vas deferens, or any other portion of the reproductive system. Your ejaculate contains semen in this instance, but there aren’t enough sperm to count because of the obstruction.
  • Non-obstructive Azoospermia: It is a condition where the formation of sperm in the testicles is either very low or non-existent. This may result from abnormalities in the pituitary gland’s functioning, the testicles’ anatomy, or other testicular components.

    We Are Ready To Help You With A Smile!

    Have Questions Or Want To Get Started?

    Causes & symptoms of azoospermia for each type

    Following are the non-obstructive causes of azoospermia:

    • Damage or trauma to the ejaculatory ducts, epididymis, or vas deferens
    • Infections
    • Inflammation
    • The pelvic region has already undergone surgical procedures
    • The growth of a cyst is referred to as cyst creation
    • Having had a vasectomy: The vas deferens are cut or clamped during a vasectomy, a medically designed permanent contraceptive procedure, to stop the flow of sperm.
    • A cystic fibrosis gene mutation results in either inadequate or no vas deferens development, which leads to the accumulation of viscous secretions that block sperm movement.

    Following are the non-obstructive causes of azoospermia:

    1. Genetic factors: Infertility may stem from specific genetic mutations, including:

    • Kallmann syndrome: A genetic (inherited) condition that is X-chromosome-related and that, if untreated, can lead to infertility.
    • Klinefelter’s syndrome: A guy has an additional X chromosome (making his chromosomal makeup XXY instead of XY). Infertility is often the end outcome, coupled with immaturity on the physical or sexual front and academic issues.
    • Deletion of the Y chromosome: Infertility is caused by the absence of crucial regions of genes on the Y chromosome, or the male chromosome, which are in charge of producing sperm.

    2. Hormone imbalances and endocrine conditions include androgen resistance, hyperprolactinemia, and hypogonadotropic hypogonadism.

    3. Ejaculatory issues include retrograde ejaculation, in which the semen enters the bladder.

    4. The testicular causes are:

    • Mumps orchitis
    • Testicular torsion
    • Tumors
    • Adverse medication reactions that reduce sperm production
    • Radiation therapies
    • Diseases like kidney failure, cirrhosis, or diabetes.
    • Varicocele

    Explain all options/conditions in that case

    • Subfertility: Subfertility occurs when a couple has been having frequent, unprotected sexual encounters for a year but is still unable to conceive a child. Therefore, the distinction from sterility is that conception is more difficult but not impossible. Issues in both genders may contribute to subfertility.
    • Infertility: Although fertilization of the egg by the sperm does happen, infertility is described as the lack of ability to get pregnant to the term for various reasons. Failure of embryo implantation, miscarriage, or ectopic pregnancy is the common term for infertility.
    • Sterility: Sterility happens when an egg and sperm never successfully fuse to form a fertilized embryo.


    The diagnosis of azoospermia or the phrase “no sperm count” might be shocking news. This illness does not automatically rule out the possibility of having biological children.

    First, you need to figure out what’s triggering the problem. After determining and resolving the root problem, your physician may recommend various treatments.

    Related Blogs
    Follow Us On

    About Authors

    Dr. Jay Mehta Fertility and IVF Specialist In Mumbai

    Dr. Jay Mehta

    Fertility and IVF Specialist


    Verified & Most Trusted One

    Dr. Jay Mehta is the Scientific Director of Shree IVF Clinic. He is a well-known Fertility and IVF Specialist and also among few doctors in the country who specializes in Embryology and Andrology.

    Know More

    Wordpress Social Share Plugin powered by Ultimatelysocial