15% of the population is affected by infertility, and 50% of infertility cases involve male factor infertility. In the case of male factor infertility, defective sperm is the only reason. In 1992 intracytoplasmic sperm injection was introduced, and it helped quite a lot of people to be benefited from this procedure.

Sperm quality is one of the most important things to be kept in mind while opting for this procedure. The fate of the embryo depends mainly on the sperm’s quality, and the development of the embryo depends upon the sperm’s epigenetic signatures.

Even if the sperm injected has some abnormal characteristics, it might lead to different problems such as miscarriages, disturbance in the early embryonic stage, congenital disability, and a failed blastocyst formation. The ability to select sperm is a very tough job, but innovations have led its way.

IMSI’s procedure helps to identify the quality of the sperms by high magnifying microscopes, which allow magnifying the sperm 6000 times compared to an ordinary microscope, which allows specifying a sperm by 400 times.

Recent studies have proved that IMSI is much better and efficient than ICSI. Couples with more than two unsuccessful ICSI-IVF cycles have been benefitted the most from this procedure. It not only increased the rate of pregnancy but also decreased the rate of miscarriages.

What is ICSI, and how does it work?

The procedure of ICSI is performed under a standard microscope, which manifests the cells 400 times. It sometimes becomes difficult to differentiate between the healthy and the unhealthy sperms at this level with ICSI. The same anomalies of the sperm are challenging to be detected with this procedure.

There are advanced techniques that help to magnify the sperms 6000 times. These techniques are known as ultra-high sperm analysis methods. The procedure of ICSI is the same, but the accuracy results are what differentiate when compared to other methods.

It is as per records that IMSI is more successful than ICSI because it gives better results because of its ability to magnify the sperms 6000 times. This high magnification enables one to distinguish between healthy sperms and abnormal sperms, resulting in better development of the embryo.

What is IMSI, and how does it work?

IVF or In-Vitro-Fertilization treatment involves the method of IMSI, which helps to identify the sperms 6000 times. The high-magnification digital imaging microscope helps separate the healthy sperms from the abnormal sperms, thus increasing the results of a positive outcome.

The high-magnification digital imaging microscope also enables microinjecting the sperms into the eggs. The suspected variations of the sperm are excluded with the help of this microscope from injecting into the eggs available.

Individual sperms are examined using the high-magnifying microscope, which helps to magnify the sperms 6000 times. This magnification helps the doctors to identify the behavior of individual sperms quickly.

Most importantly, it helps to include the healthy sperms without any abnormalities in the process of IVF. Thus, if you have a poor result from the repeated ICSI-IVF cycle, you may opt for this procedure, which will increase the chances of a positive impact.

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Outcome measures of both the procedures

According to recent studies, it was measured that which technique is healthier. The main results of ICSI are compared with IMSI in various groups:

  • Male infertility
  • Repeated unsuccessful implantation
  • Non-selected patients

The outcomes of these tests helped to know the effects of these techniques. This also helped determine the most appropriate group of patents, who will get benefit from the method.

The IMSI procedure helped increase the chances of fertilization and select the high-quality sperms for the process in case of the group with male infertility. The quality of embryo in the case of male infertility was also the best using this procedure. The percentage of pregnancy rates also increased in the ones who have repeated unsuccessful ICSI-IVF cycles.

There were no significant effects in a non-selected group of patients observed with IMSI. Thus, we can conclude that IMSI is one of the best techniques used in treating male infertility. The result of IMSI’s outcome is positive because of the use of high-magnifying microscopes in this procedure.
The positive effect that was observed in the case of IMSI is mainly on the male infertility issues and repeated unsuccessful implantation.

The results confirmed that IMSI could benefit those who have repeatedly gotten poor results in unsuccessful IVF cycles and male factor infertility. It is much more advantageous than ICSI. In some cases, patients get a positive outcome from ICSI, but the guaranteed and accurate results are seen from IMSI.

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Why can IMSI help patients with failed ICSI-IVF?

The chances of a healthy pregnancy depend hugely on the quality of the embryo. The quality of the embryo depends hugely upon the quality of the sperm and the egg. The inferior qualities of sperm sometimes create an embryo, but it is not favored in the fertilization process as it can result in miscarriage.

The sperm abnormalities are found out by high-magnifying microscopes, which can magnify 6000 times. The embryologists can find out the anomalies in the sperm more accurately by using this microscope. This helps to increase the chances of the best quality embryo if the sperm is without any abnormalities.

In the case of ICSI, it is entirely different. The mature eggs helping in successful fertilization is the main achievement of the ICSI cycle. But the mature eggs do not always result in a successful pregnancy; it may cause early miscarriage due to the sperm abnormalities that remain undetected in this procedure.

Patients who need ICSI are having:

  • A record of unsuccessful fertilization with IVF.
  • Low sperm count
  • Low sperm motility or morphology
  • Surgically retrieving sperm
  • A record of abnormal fertilization

Patients who need IMSI are having:

  • Repeated unsuccessful ICSI-IVF cycle
  • Record of miscarriage
  • The quality of embryos are deficient in the past cycles
  • Abnormal sperms detected in semen analysis

According to records, IMSI is specifically for the ones with unsuccessful ICSI attempts.

The bottom line

It gives immense joy to a couple when they become parents. It is usual for a few couples to give birth to a child, but for some couples, giving birth to a child is like a dream come true. Women and men’s infertility is the substantial enemy of the life of a couple. This causes harm to the couple, both physically and mentally.

The ability to conceive is one of the powers gifted to women. But all women are not lucky in this case because it also involves the fertilize sperms of the male counterpart. Advanced techniques are now helping the couple to fertilize and have their baby with their sperm.

IMSI-IVF, in this case, is much better than standard ICSI as it will give you more hope to become parents and complete your family without any complication in the new-born. You can rely on the high-standard magnifying microscopes being used in this technique for better fertilization. This procedure is now in an advanced stage, and studies are going on to improve this procedure more as it is a time-consuming process and expensive. Hope to see more positive results of this technique in the near future and bringing joy to a family.

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Dr. Jay Mehta Fertility and IVF Specialist In Mumbai

Dr. Jay Mehta

Fertility and IVF Specialist

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Dr. Jay Mehta is the Scientific Director of Shree IVF Clinic. He is a well-known Fertility and IVF Specialist and also among few doctors in the country who specializes in Embryology and Andrology.

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