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Is IVF more Successful the Second Time?



Dr Jay Mehta

Scientific Director & IVF Specialist with 10+ years of experience




Is there a possibility of pregnancy after second IVF cycle?

Is the success rate higher in IVF for the second time?

Is a second IVF cycle more effective?  

Before knowing that,

It is very important for every patient to know the Facts that:

  • IVF success rate is 35-40%.
  • Patients may need at least 2 or 3 IVF cycles to be successful.
  • In order to successfully undergo IVF therapy, you must be mentally prepared to try it two to three times. It might require more effort than you’ve put in thus far.

The crucial consideration is whenever IVF occurs for the second time, your doctors re-examine all the parameters. 

If in the first IVF cycle the doctor finds problems in the embryo, problems in the endometrium, egg factor, sperm factor, or endocrinological issues in the first cycle, then the doctor will try to see these things again before starting the 2nd IVF.

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Also Read : Why Does IVF Fail?

Even if no problem is visible after all these tests, the success rate of 2nd IVF will be 35-40%. Because a 35-40% success rate is per IVF cycle. Patients seem to add these percentile numbers, which is not the case.

No matter how hard the doctors and patients have worked, luck also plays a very important role in the IVF success rate and you have to accept it.  

How far along in the IVF process you are when it is successful is determined by luck. The doctor will sincerely put in a lot of effort toward this end.

The patient takes their medication as directed and always follows their doctor’s instructions. Sincere to say, a crucial part of IVF treatment is played by the female. Since most women are emotional, they naturally never skip taking their medications.

After giving it their all, the percentage amounted to at least a level between 35 and 40.  It may hurt to hear this, but that is the assurance. You may have observed numerous patients who underwent four to five attempts but were unsuccessful in becoming pregnant. Most likely, this is unlucky.

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How to improve the success rate of IVF implantation after IVF failure?

Corrective measures have to be taken as far as uterine factors are concerned; embryonic factors are a mandate; how do we correct uterine factors?

First, we need to identify and we just said that we have to do all those tests and if we find a fibroid, and if a fibroid is greater than 4 cm, or you find a fibroid that is greater than 2 cm, but it is jutting into the uterine cavity, so it becomes a space-occupying lesion within the uterus, doesn’t allow the embryo to attach to the uterus. We should consider removing that kind of fibroids.

Second, if you have some kind of small growths like polyps, then that needs to be removed. If there is a band inside the uterus called the intrauterine septum, or adhesions cynical, yes, they need to be cut and the uterus needs to be optimized with medications to improve upon the uterine lining before you can think about the next uterine transfer when you do not find these kinds of issues and still there an implantation failure, then one can think about the genetic profile of the endometrium. The uterus can be understood as the endometrial receptivity assay. It is called the ERA test.


Dr Jay Mehta

Scientific Director & IVF Specialist with 10+ years of experience





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